Drug interactions
Deflazacort + Penicillin g
Severity: Moderate
Deflazacort and Penicillin g: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose penicillin G can cause hypokalemia through delivery of a nonreabsorbable anion to the distal nephron, which increases potassium loss. Deflazacort, a corticosteroid, has mineralocorticoid activity that can also lower potassium, so the effects may add together.
What this interaction means in plain words
Deflazacort and Penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Penicillin g belongs to Anti Bacterial.
Why it happens
Additive renal potassium wasting from penicillin G and corticosteroid mineralocorticoid effect.
What to do
Monitor serum potassium during high-dose penicillin G therapy with deflazacort and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Deflazacort and Penicillin g, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Penicillin g
- Amifampridine + Penicillin g Moderate
- Amiloride + Penicillin g Moderate
- Bcg vaccine live + Penicillin g Moderate
- Cholera vaccine + Penicillin g Moderate
- Colestipol + Penicillin g Moderate
- Demeclocycline + Penicillin g Moderate
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Penicillin g?
MediHelp rates the interaction as moderate. Deflazacort and Penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose penicillin G can cause hypokalemia through delivery of a nonreabsorbable anion to the distal nephron, which increases potassium loss. Deflazacort, a corticosteroid, has mineralocorticoid activity that can also lower potassium, so the effects may add together.
How serious is the interaction between Deflazacort and Penicillin g?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium during high-dose penicillin G therapy with deflazacort and replace potassium as needed.
What other medicines interact with Penicillin g?
MediHelp also lists interactions of Penicillin g with, for example, Amifampridine, Amiloride, Bcg vaccine live. The full list is on the Penicillin g page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
