Drug interactions
Cholera vaccine + Penicillin g
Severity: Moderate
Cholera vaccine and Penicillin g: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The oral live attenuated cholera vaccine contains a bacterial strain that may be killed by antibiotics, which could reduce the immune response. Penicillin G is a systemic antibiotic with activity against many bacteria.
What this interaction means in plain words
Cholera vaccine and Penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity against the live vaccine strain may reduce vaccine organism viability and immunogenicity.
What to do
Avoid giving the live oral cholera vaccine to patients who have taken systemic antibiotics in the preceding 14 days, and delay antibiotics after vaccination where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Penicillin g
- Amifampridine + Penicillin g Moderate
- Amiloride + Penicillin g Moderate
- Bcg vaccine live + Penicillin g Moderate
- Colestipol + Penicillin g Moderate
- Deflazacort + Penicillin g Moderate
- Demeclocycline + Penicillin g Moderate
Frequently asked questions
Can I take Cholera vaccine with Penicillin g?
MediHelp rates the interaction as moderate. Cholera vaccine and Penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The oral live attenuated cholera vaccine contains a bacterial strain that may be killed by antibiotics, which could reduce the immune response. Penicillin G is a systemic antibiotic with activity against many bacteria.
How serious is the interaction between Cholera vaccine and Penicillin g?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving the live oral cholera vaccine to patients who have taken systemic antibiotics in the preceding 14 days, and delay antibiotics after vaccination where feasible.
What other medicines interact with Penicillin g?
MediHelp also lists interactions of Penicillin g with, for example, Amifampridine, Amiloride, Bcg vaccine live. The full list is on the Penicillin g page.
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