Drug interactions
Colestipol + Penicillin g
Severity: Moderate
Colestipol and Penicillin g: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colestipol can reduce the absorption of oral penicillin G. This may lower antibiotic levels and weaken the therapeutic effect.
What this interaction means in plain words
Colestipol and Penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colestipol belongs to Cardiovascular; Penicillin g belongs to Anti Bacterial.
Why it happens
Colestipol adsorbs penicillin G in the gut lumen, reducing its absorption.
What to do
Give oral penicillin at least 1 hour before or 4 hours after colestipol. Consider a parenteral route for serious infections.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Other interactions of Penicillin g
- Amifampridine + Penicillin g Moderate
- Amiloride + Penicillin g Moderate
- Bcg vaccine live + Penicillin g Moderate
- Cholera vaccine + Penicillin g Moderate
- Deflazacort + Penicillin g Moderate
- Demeclocycline + Penicillin g Moderate
Frequently asked questions
Can I take Colestipol with Penicillin g?
MediHelp rates the interaction as moderate. Colestipol and Penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colestipol can reduce the absorption of oral penicillin G. This may lower antibiotic levels and weaken the therapeutic effect.
How serious is the interaction between Colestipol and Penicillin g?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral penicillin at least 1 hour before or 4 hours after colestipol. Consider a parenteral route for serious infections.
What other medicines interact with Colestipol?
MediHelp also lists interactions of Colestipol with, for example, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide, Atenolol-chlorthalidone. The full list is on the Colestipol page.
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