Drug interactions
Amiloride + Tizanidine
Severity: Minor
Amiloride and Tizanidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tizanidine is an alpha-2 agonist that lowers blood pressure, so adding a diuretic like amiloride may produce additive hypotension. The effect is usually modest and manageable.
What this interaction means in plain words
Amiloride and Tizanidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiloride belongs to Cardiovascular; Tizanidine belongs to Musculoskeletal.
Why it happens
Additive blood-pressure lowering through central alpha-2 agonism and diuretic volume reduction.
What to do
Monitor blood pressure when starting or adjusting either drug, and counsel patients about orthostatic dizziness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Tizanidine?
MediHelp rates the interaction as minor. Amiloride and Tizanidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tizanidine is an alpha-2 agonist that lowers blood pressure, so adding a diuretic like amiloride may produce additive hypotension. The effect is usually modest and manageable.
How serious is the interaction between Amiloride and Tizanidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting or adjusting either drug, and counsel patients about orthostatic dizziness.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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