Drug reference
tizanidine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Musculoskeletal (Muscle Relaxants)
Mechanism of action
Alpha-2 adrenergic receptor agonist structurally related to clonidine; increases presynaptic inhibition of motor neurons
Common side effects
- Asthenia
- Dry mouth
- Constipation
- Dizziness
- Somnolence
- Blurred vision
Contraindications
- Hypersensitivity Concomitant ciprofloxacin or fluvoxamine, or other potent CYP1A2 inhibitors
Known interactions (4)
- ciprofloxacin + tizanidine Contraindicated
- fluvoxamine + tizanidine Contraindicated
- Isotretinoin + tizanidine Moderate
- Piroxicam + tizanidine Moderate
Related conditions
Frequently asked questions
What drug class is tizanidine?
tizanidine belongs to: Musculoskeletal.
How does tizanidine work?
Alpha-2 adrenergic receptor agonist structurally related to clonidine; increases presynaptic inhibition of motor neurons
What are the common side effects of tizanidine?
Asthenia, Dry mouth, Constipation, Dizziness, Somnolence, Blurred vision
Which drugs interact with tizanidine?
ciprofloxacin, fluvoxamine, Isotretinoin, Piroxicam
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