Drug interactions
fluvoxamine + tizanidine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Marked ↑ tizanidine levels → coma/hypotension risk.
Mechanism of action
CYP1A2 inhibition.
Clinical management
Avoid combination completely.
Drug reference
References
Frequently asked questions
Can I take fluvoxamine with tizanidine?
The interaction is rated: Contraindicated. Marked ↑ tizanidine levels → coma/hypotension risk.
How serious is the interaction between fluvoxamine and tizanidine?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between fluvoxamine and tizanidine managed?
Avoid combination completely.
Why do fluvoxamine and tizanidine interact?
CYP1A2 inhibition.
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