Drug interactions
Aminohippurate + Amlodipine-olmesartan-hydrochlorothiazide
Severity: Minor
Aminohippurate and Amlodipine-olmesartan-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is secreted by the renal organic anion pathway and may compete with aminohippurate. This can reduce aminohippurate clearance and distort renal plasma flow measurements.
What this interaction means in plain words
Aminohippurate and Amlodipine-olmesartan-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion transport.
What to do
Interpret effective renal plasma flow results cautiously in patients taking hydrochlorothiazide. Consider the interaction when scheduling the diagnostic test.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Aminohippurate with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp rates the interaction as minor. Aminohippurate and Amlodipine-olmesartan-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide is secreted by the renal organic anion pathway and may compete with aminohippurate. This can reduce aminohippurate clearance and distort renal plasma flow measurements.
How serious is the interaction between Aminohippurate and Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Interpret effective renal plasma flow results cautiously in patients taking hydrochlorothiazide. Consider the interaction when scheduling the diagnostic test.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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