Drug interactions
Aminohippurate + Mefenamic acid
Severity: Minor
Aminohippurate and Mefenamic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefenamic acid is an organic anion that competes with aminohippurate for tubular secretion, which may delay its clearance. This can lead to an underestimate of effective renal plasma flow when aminohippurate is used as a diagnostic agent.
What this interaction means in plain words
Aminohippurate and Mefenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for organic anion transporter-mediated renal tubular secretion.
What to do
Where possible, hold the NSAID before renal plasma flow testing, or interpret the result with the interference in mind.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Aminohippurate with Mefenamic acid?
MediHelp rates the interaction as minor. Aminohippurate and Mefenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mefenamic acid is an organic anion that competes with aminohippurate for tubular secretion, which may delay its clearance. This can lead to an underestimate of effective renal plasma flow when aminohippurate is used as a diagnostic agent.
How serious is the interaction between Aminohippurate and Mefenamic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, hold the NSAID before renal plasma flow testing, or interpret the result with the interference in mind.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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