Drug interactions
Amiodarone + Amlodipine-benazepril
Severity: Moderate
Amiodarone and Amlodipine-benazepril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone has vasodilating and negative chronotropic effects that may add to the blood pressure lowering of amlodipine and benazepril. Hypotension and bradycardia may occur.
What this interaction means in plain words
Amiodarone and Amlodipine-benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Amlodipine-benazepril belongs to Cardiovascular.
Why it happens
Additive vasodilatory and hypotensive effects; amiodarone may also modestly raise amlodipine exposure through CYP3A4 inhibition.
What to do
Monitor blood pressure and heart rate when starting or adjusting amiodarone, and adjust antihypertensive doses if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Amlodipine-benazepril?
MediHelp rates the interaction as moderate. Amiodarone and Amlodipine-benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone has vasodilating and negative chronotropic effects that may add to the blood pressure lowering of amlodipine and benazepril. Hypotension and bradycardia may occur.
How serious is the interaction between Amiodarone and Amlodipine-benazepril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting amiodarone, and adjust antihypertensive doses if needed.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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