Drug interactions
Amiodarone + Axitinib
Severity: Moderate
Amiodarone and Axitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone is a weak to moderate CYP3A4 inhibitor and can raise axitinib concentrations. This may increase axitinib adverse effects such as hypertension, diarrhoea and hepatotoxicity.
What this interaction means in plain words
Amiodarone and Axitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Axitinib belongs to Oncology.
Why it happens
Amiodarone inhibits CYP3A4-mediated metabolism of axitinib.
What to do
Monitor blood pressure and tolerability, and reduce the axitinib dose if adverse effects appear. Consider alternatives if axitinib toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Amiodarone with Axitinib?
MediHelp rates the interaction as moderate. Amiodarone and Axitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone is a weak to moderate CYP3A4 inhibitor and can raise axitinib concentrations. This may increase axitinib adverse effects such as hypertension, diarrhoea and hepatotoxicity.
How serious is the interaction between Amiodarone and Axitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and tolerability, and reduce the axitinib dose if adverse effects appear. Consider alternatives if axitinib toxicity occurs.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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