Drug interactions
Amiodarone + Canagliflozin-metformin
Severity: Minor
Amiodarone and Canagliflozin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may reduce renal tubular secretion of metformin, potentially raising metformin levels. Higher exposure could increase the risk of gastrointestinal effects and, rarely, lactic acidosis.
What this interaction means in plain words
Amiodarone and Canagliflozin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Canagliflozin-metformin belongs to Endocrine.
Why it happens
Possible competition for renal cationic transporters (OCT2/MATE) reducing metformin clearance.
What to do
No dose change is usually required. Monitor renal function and for symptoms of lactic acidosis, particularly in patients with reduced eGFR.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Canagliflozin-metformin?
MediHelp rates the interaction as minor. Amiodarone and Canagliflozin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone may reduce renal tubular secretion of metformin, potentially raising metformin levels. Higher exposure could increase the risk of gastrointestinal effects and, rarely, lactic acidosis.
How serious is the interaction between Amiodarone and Canagliflozin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required. Monitor renal function and for symptoms of lactic acidosis, particularly in patients with reduced eGFR.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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