Drug interactions
Amiodarone + Cobimetinib
Severity: Moderate
Amiodarone and Cobimetinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may inhibit CYP3A4 and raise cobimetinib exposure, increasing risks such as serous retinopathy, hemorrhage, rhabdomyolysis and liver toxicity.
What this interaction means in plain words
Amiodarone and Cobimetinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Cobimetinib belongs to Oncology.
Why it happens
Amiodarone inhibits CYP3A4-mediated metabolism of cobimetinib.
What to do
Prefer an alternative antiarrhythmic. If unavoidable, reduce the cobimetinib dose as in labeling for moderate CYP3A inhibitors and monitor for toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Cobimetinib
- Cobimetinib + Efavirenz Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Amobarbital + Cobimetinib Major
- Apalutamide + Cobimetinib Major
- Aprepitant + Cobimetinib Major
- Bosentan + Cobimetinib Major
Frequently asked questions
Can I take Amiodarone with Cobimetinib?
MediHelp rates the interaction as moderate. Amiodarone and Cobimetinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may inhibit CYP3A4 and raise cobimetinib exposure, increasing risks such as serous retinopathy, hemorrhage, rhabdomyolysis and liver toxicity.
How serious is the interaction between Amiodarone and Cobimetinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antiarrhythmic. If unavoidable, reduce the cobimetinib dose as in labeling for moderate CYP3A inhibitors and monitor for toxicity.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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