Drug interactions
Amiodarone + Cyclophosphamide
Severity: Moderate
Amiodarone and Cyclophosphamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone has been associated with pulmonary toxicity, and cyclophosphamide can also cause lung and cardiac toxicity. Their combination may add to the risk of these organ injuries, though data are limited to case reports.
What this interaction means in plain words
Amiodarone and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Cyclophosphamide belongs to Oncology.
Why it happens
Additive pulmonary and cardiac toxicity; a pharmacokinetic mechanism is not established.
What to do
Monitor respiratory symptoms and cardiac function, and obtain pulmonary evaluation if cough or dyspnea develops. Consider alternatives to amiodarone when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amiodarone and Cyclophosphamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Cyclophosphamide
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Cyclophosphamide?
MediHelp rates the interaction as moderate. Amiodarone and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone has been associated with pulmonary toxicity, and cyclophosphamide can also cause lung and cardiac toxicity. Their combination may add to the risk of these organ injuries, though data are limited to case reports.
How serious is the interaction between Amiodarone and Cyclophosphamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory symptoms and cardiac function, and obtain pulmonary evaluation if cough or dyspnea develops. Consider alternatives to amiodarone when feasible.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
