Drug interactions
Amiodarone + Deflazacort
Severity: Moderate
Amiodarone and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone, a moderate CYP3A4 inhibitor, can raise exposure to the active metabolite of deflazacort, increasing corticosteroid adverse effects. Deflazacort labeling recommends a reduced dose with moderate CYP3A4 inhibitors.
What this interaction means in plain words
Amiodarone and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Deflazacort belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by amiodarone increases exposure to the active deflazacort metabolite.
What to do
Reduce the deflazacort dose to about one-third of the usual dose as labeled and monitor for steroid-related adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amiodarone and Deflazacort, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Amiodarone with Deflazacort?
MediHelp rates the interaction as moderate. Amiodarone and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone, a moderate CYP3A4 inhibitor, can raise exposure to the active metabolite of deflazacort, increasing corticosteroid adverse effects. Deflazacort labeling recommends a reduced dose with moderate CYP3A4 inhibitors.
How serious is the interaction between Amiodarone and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the deflazacort dose to about one-third of the usual dose as labeled and monitor for steroid-related adverse effects.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
