Drug interactions
Amiodarone + Docetaxel
Severity: Moderate
Amiodarone and Docetaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may increase docetaxel exposure and toxicity such as neutropenia, fluid retention or neuropathy. The evidence is largely theoretical.
What this interaction means in plain words
Amiodarone and Docetaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Docetaxel belongs to Oncology.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by amiodarone may reduce docetaxel clearance.
What to do
Monitor blood counts and signs of docetaxel toxicity, and reduce the docetaxel dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Docetaxel
Frequently asked questions
Can I take Amiodarone with Docetaxel?
MediHelp rates the interaction as moderate. Amiodarone and Docetaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may increase docetaxel exposure and toxicity such as neutropenia, fluid retention or neuropathy. The evidence is largely theoretical.
How serious is the interaction between Amiodarone and Docetaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of docetaxel toxicity, and reduce the docetaxel dose if toxicity develops.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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