Drug interactions
Armodafinil + Entrectinib
Severity: Major
Armodafinil and Entrectinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib is a CYP3A4 substrate, and induction by armodafinil may reduce its exposure and antitumor effect. Labeling recommends avoiding moderate and strong CYP3A inducers.
What this interaction means in plain words
Armodafinil and Entrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Armodafinil belongs to Central Nervous System; Entrectinib belongs to Oncology.
Why it happens
Armodafinil induces CYP3A4, increasing the clearance of entrectinib.
What to do
Avoid concomitant use and select a non-inducing alternative. If unavoidable, monitor tumor response closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Armodafinil
Other interactions of Entrectinib
Frequently asked questions
Can I take Armodafinil with Entrectinib?
MediHelp rates the interaction as major. Armodafinil and Entrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Entrectinib is a CYP3A4 substrate, and induction by armodafinil may reduce its exposure and antitumor effect. Labeling recommends avoiding moderate and strong CYP3A inducers.
How serious is the interaction between Armodafinil and Entrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and select a non-inducing alternative. If unavoidable, monitor tumor response closely.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Cyclosporine, Elacestrant. The full list is on the Armodafinil page.
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