Drug interactions
Amiodarone + Erdafitinib
Severity: Moderate
Amiodarone and Erdafitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may inhibit CYP2C9 and raise erdafitinib levels, increasing the risk of hyperphosphatemia, ocular and skin toxicity. Erdafitinib may also inhibit P-glycoprotein and increase amiodarone exposure.
What this interaction means in plain words
Amiodarone and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Erdafitinib belongs to Oncology.
Why it happens
Amiodarone inhibits CYP2C9 metabolism of erdafitinib, and erdafitinib may inhibit P-glycoprotein efflux of amiodarone.
What to do
Monitor for erdafitinib adverse reactions and consider dose reduction. Monitor heart rate, ECG and amiodarone toxicity, and separate dosing as labeled.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Erdafitinib
Frequently asked questions
Can I take Amiodarone with Erdafitinib?
MediHelp rates the interaction as moderate. Amiodarone and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may inhibit CYP2C9 and raise erdafitinib levels, increasing the risk of hyperphosphatemia, ocular and skin toxicity. Erdafitinib may also inhibit P-glycoprotein and increase amiodarone exposure.
How serious is the interaction between Amiodarone and Erdafitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erdafitinib adverse reactions and consider dose reduction. Monitor heart rate, ECG and amiodarone toxicity, and separate dosing as labeled.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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