Drug interactions
Amiodarone + Erlotinib
Severity: Minor
Amiodarone and Erlotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may increase erlotinib exposure, with more rash, diarrhea or other adverse effects. Erlotinib is also metabolized by CYP3A4, which amiodarone inhibits modestly.
What this interaction means in plain words
Amiodarone and Erlotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Erlotinib belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein and CYP3A4 by amiodarone may reduce erlotinib clearance.
What to do
Monitor for erlotinib adverse effects such as rash and diarrhea, and reduce the dose if they become troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Amiodarone with Erlotinib?
MediHelp rates the interaction as minor. Amiodarone and Erlotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone may increase erlotinib exposure, with more rash, diarrhea or other adverse effects. Erlotinib is also metabolized by CYP3A4, which amiodarone inhibits modestly.
How serious is the interaction between Amiodarone and Erlotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erlotinib adverse effects such as rash and diarrhea, and reduce the dose if they become troublesome.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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