Drug interactions
Amiodarone + Fludrocortisone
Severity: Moderate
Amiodarone and Fludrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone causes potassium loss, and hypokalemia increases the risk of QT prolongation and torsades de pointes with amiodarone. Pharmacokinetic effects through CYP3A4 or P-glycoprotein are of minor importance.
What this interaction means in plain words
Amiodarone and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Fludrocortisone belongs to Endocrine.
Why it happens
Mineralocorticoid-induced hypokalemia adds to amiodarone's proarrhythmic potential; minor transporter and enzyme effects are theoretical.
What to do
Monitor serum potassium and magnesium regularly and replace deficits promptly. Check the ECG if electrolyte disturbances or symptoms of arrhythmia occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Amiodarone with Fludrocortisone?
MediHelp rates the interaction as moderate. Amiodarone and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fludrocortisone causes potassium loss, and hypokalemia increases the risk of QT prolongation and torsades de pointes with amiodarone. Pharmacokinetic effects through CYP3A4 or P-glycoprotein are of minor importance.
How serious is the interaction between Amiodarone and Fludrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and replace deficits promptly. Check the ECG if electrolyte disturbances or symptoms of arrhythmia occur.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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