Drug interactions
Amiodarone + Flurbiprofen
Severity: Minor
Amiodarone and Flurbiprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits CYP2C9 and may raise flurbiprofen exposure, increasing the risk of NSAID adverse effects such as GI bleeding and renal effects. The magnitude is modest and not well quantified.
What this interaction means in plain words
Amiodarone and Flurbiprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Flurbiprofen belongs to Musculoskeletal.
Why it happens
Amiodarone inhibition of CYP2C9-mediated flurbiprofen metabolism.
What to do
Use the lowest effective flurbiprofen dose and watch for GI or renal adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Flurbiprofen?
MediHelp rates the interaction as minor. Amiodarone and Flurbiprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone inhibits CYP2C9 and may raise flurbiprofen exposure, increasing the risk of NSAID adverse effects such as GI bleeding and renal effects. The magnitude is modest and not well quantified.
How serious is the interaction between Amiodarone and Flurbiprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective flurbiprofen dose and watch for GI or renal adverse effects.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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