Drug interactions
Amiodarone + Fluvastatin
Severity: Minor
Amiodarone and Fluvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits CYP2C9, the main enzyme clearing fluvastatin, so fluvastatin exposure may rise modestly. This could increase the risk of statin-related muscle toxicity, although the clinical effect is generally small.
What this interaction means in plain words
Amiodarone and Fluvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Fluvastatin belongs to Cardiovascular.
Why it happens
Amiodarone inhibits CYP2C9-mediated metabolism of fluvastatin.
What to do
Ask patients to report unexplained muscle pain or weakness and check CK if symptoms occur. Dose reduction is rarely needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Fluvastatin
- Cyclosporine + Fluvastatin Major
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
Frequently asked questions
Can I take Amiodarone with Fluvastatin?
MediHelp rates the interaction as minor. Amiodarone and Fluvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone inhibits CYP2C9, the main enzyme clearing fluvastatin, so fluvastatin exposure may rise modestly. This could increase the risk of statin-related muscle toxicity, although the clinical effect is generally small.
How serious is the interaction between Amiodarone and Fluvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients to report unexplained muscle pain or weakness and check CK if symptoms occur. Dose reduction is rarely needed.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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