Drug interactions
Amiodarone + Glipizide-metformin
Severity: Minor
Amiodarone and Glipizide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may modestly raise metformin levels through competition for renal tubular transport, and it can inhibit CYP2C9, which may increase glipizide exposure. Clinical consequences are generally limited but hypoglycemia is possible.
What this interaction means in plain words
Amiodarone and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Glipizide-metformin belongs to Endocrine.
Why it happens
Possible inhibition of renal cationic transport (OCT/MATE) of metformin and CYP2C9 inhibition affecting glipizide.
What to do
Monitor blood glucose when starting or stopping amiodarone and adjust antidiabetic doses if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Glipizide-metformin?
MediHelp rates the interaction as minor. Amiodarone and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone may modestly raise metformin levels through competition for renal tubular transport, and it can inhibit CYP2C9, which may increase glipizide exposure. Clinical consequences are generally limited but hypoglycemia is possible.
How serious is the interaction between Amiodarone and Glipizide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping amiodarone and adjust antidiabetic doses if needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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