Drug interactions
Amiodarone + Glyburide-metformin
Severity: Minor
Amiodarone and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may reduce renal tubular secretion of metformin and raise its concentrations. The clinical effect is generally modest, but higher metformin exposure can increase the risk of adverse effects, including lactic acidosis in susceptible patients.
What this interaction means in plain words
Amiodarone and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Glyburide-metformin belongs to Endocrine.
Why it happens
Possible inhibition of renal organic cation transporters involved in metformin secretion; the evidence is limited.
What to do
No routine change is needed; monitor renal function and glycemic control, and watch for gastrointestinal intolerance or lactic acidosis symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Glyburide-metformin?
MediHelp rates the interaction as minor. Amiodarone and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone may reduce renal tubular secretion of metformin and raise its concentrations. The clinical effect is generally modest, but higher metformin exposure can increase the risk of adverse effects, including lactic acidosis in susceptible patients.
How serious is the interaction between Amiodarone and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor renal function and glycemic control, and watch for gastrointestinal intolerance or lactic acidosis symptoms.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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