Drug interactions
Amiodarone + Ibuprofen
Severity: Minor
Amiodarone and Ibuprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits CYP2C9, which is a route of ibuprofen metabolism, so ibuprofen exposure could increase somewhat. The effect is likely modest, though NSAIDs may also affect blood pressure and fluid balance in cardiac patients.
What this interaction means in plain words
Amiodarone and Ibuprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Ibuprofen belongs to Musculoskeletal.
Why it happens
Inhibition of CYP2C9-mediated ibuprofen metabolism by amiodarone.
What to do
No dose change is generally needed. Use the lowest effective ibuprofen dose and watch for GI or renal adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Ibuprofen?
MediHelp rates the interaction as minor. Amiodarone and Ibuprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone inhibits CYP2C9, which is a route of ibuprofen metabolism, so ibuprofen exposure could increase somewhat. The effect is likely modest, though NSAIDs may also affect blood pressure and fluid balance in cardiac patients.
How serious is the interaction between Amiodarone and Ibuprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Use the lowest effective ibuprofen dose and watch for GI or renal adverse effects.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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