Drug interactions
Amiodarone + Ifosfamide
Severity: Moderate
Amiodarone and Ifosfamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide is activated to its active metabolites partly by CYP3A4 and CYP2B6, and amiodarone inhibits CYP3A4. This could reduce activation and efficacy while possibly increasing neurotoxic metabolite formation, but the clinical effect is not well established.
What this interaction means in plain words
Amiodarone and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Ifosfamide belongs to Oncology.
Why it happens
CYP3A4 inhibition by amiodarone may alter ifosfamide bioactivation and metabolite profile.
What to do
Monitor for reduced antitumor response and for neurotoxicity during ifosfamide therapy. Consider an alternative antiarrhythmic if the oncology team is concerned.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Amiodarone with Ifosfamide?
MediHelp rates the interaction as moderate. Amiodarone and Ifosfamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide is activated to its active metabolites partly by CYP3A4 and CYP2B6, and amiodarone inhibits CYP3A4. This could reduce activation and efficacy while possibly increasing neurotoxic metabolite formation, but the clinical effect is not well established.
How serious is the interaction between Amiodarone and Ifosfamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antitumor response and for neurotoxicity during ifosfamide therapy. Consider an alternative antiarrhythmic if the oncology team is concerned.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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