Drug interactions
Amiodarone + Irinotecan
Severity: Moderate
Amiodarone and Irinotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits CYP3A4 and P-glycoprotein, which may alter irinotecan disposition. Irinotecan toxicity such as diarrhea and neutropenia could increase, although the effect is mostly theoretical.
What this interaction means in plain words
Amiodarone and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Irinotecan belongs to Oncology.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by amiodarone may change irinotecan and SN-38 exposure.
What to do
Monitor for severe diarrhea and neutropenia and check blood counts regularly. Reduce the irinotecan dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Frequently asked questions
Can I take Amiodarone with Irinotecan?
MediHelp rates the interaction as moderate. Amiodarone and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone inhibits CYP3A4 and P-glycoprotein, which may alter irinotecan disposition. Irinotecan toxicity such as diarrhea and neutropenia could increase, although the effect is mostly theoretical.
How serious is the interaction between Amiodarone and Irinotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for severe diarrhea and neutropenia and check blood counts regularly. Reduce the irinotecan dose if toxicity occurs.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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