Drug interactions
Amiodarone + Isoflurane
Severity: Moderate
Amiodarone and Isoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoflurane can prolong the QT interval and, with amiodarone, may increase the risk of arrhythmia and bradycardia or hypotension during anesthesia. The clinical risk is greatest in patients with other proarrhythmic factors.
What this interaction means in plain words
Amiodarone and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Isoflurane belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization and conduction, with additive hemodynamic depression.
What to do
Inform the anesthesia team and continue continuous ECG monitoring during surgery. Keep electrolytes normal and have treatment for bradycardia and hypotension available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Isoflurane
Frequently asked questions
Can I take Amiodarone with Isoflurane?
MediHelp rates the interaction as moderate. Amiodarone and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoflurane can prolong the QT interval and, with amiodarone, may increase the risk of arrhythmia and bradycardia or hypotension during anesthesia. The clinical risk is greatest in patients with other proarrhythmic factors.
How serious is the interaction between Amiodarone and Isoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team and continue continuous ECG monitoring during surgery. Keep electrolytes normal and have treatment for bradycardia and hypotension available.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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