Drug interactions
Amiodarone + Istradefylline
Severity: Moderate
Amiodarone and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at the 40 mg dose can raise exposure to CYP3A4 and P-glycoprotein substrates, which may increase amiodarone concentrations. This could raise the risk of bradycardia, QT prolongation and other amiodarone toxicity.
What this interaction means in plain words
Amiodarone and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline inhibits CYP3A4 and P-glycoprotein at higher doses.
What to do
Keep istradefylline at 20 mg/day where possible and monitor heart rate and ECG. Consider reducing the amiodarone dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Amiodarone with Istradefylline?
MediHelp rates the interaction as moderate. Amiodarone and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Istradefylline at the 40 mg dose can raise exposure to CYP3A4 and P-glycoprotein substrates, which may increase amiodarone concentrations. This could raise the risk of bradycardia, QT prolongation and other amiodarone toxicity.
How serious is the interaction between Amiodarone and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep istradefylline at 20 mg/day where possible and monitor heart rate and ECG. Consider reducing the amiodarone dose if toxicity appears.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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