Drug interactions
Amiodarone + Larotrectinib
Severity: Minor
Amiodarone and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate with weak inhibitory activity on CYP3A4 and may modestly raise amiodarone concentrations. Clinical impact is probably small but amiodarone toxicity is serious.
What this interaction means in plain words
Amiodarone and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib reducing amiodarone metabolism.
What to do
Monitor heart rate and ECG when starting larotrectinib; adjust the amiodarone dose only if signs of excess appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Larotrectinib
Frequently asked questions
Can I take Amiodarone with Larotrectinib?
MediHelp rates the interaction as minor. Amiodarone and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate with weak inhibitory activity on CYP3A4 and may modestly raise amiodarone concentrations. Clinical impact is probably small but amiodarone toxicity is serious.
How serious is the interaction between Amiodarone and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG when starting larotrectinib; adjust the amiodarone dose only if signs of excess appear.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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