Drug interactions
Amiodarone + Ledipasvir-sofosbuvir
Severity: Major
Amiodarone and Ledipasvir-sofosbuvir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Coadministration of amiodarone with sofosbuvir-containing regimens has been associated with serious symptomatic bradycardia, including fatalities and pacemaker placement. Risk is higher with beta blockers, underlying cardiac disease or advanced liver disease.
What this interaction means in plain words
Amiodarone and Ledipasvir-sofosbuvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Ledipasvir-sofosbuvir belongs to Anti Virals.
Why it happens
The mechanism is not established; an additive effect on cardiac conduction is suspected.
What to do
Avoid the combination when possible; if no alternative exists, monitor the heart rate in a hospital setting for at least the first 48 hours and then daily self-monitoring or outpatient checks for the first weeks.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amiodarone and Ledipasvir-sofosbuvir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Ledipasvir-sofosbuvir?
MediHelp rates the interaction as major. Amiodarone and Ledipasvir-sofosbuvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Coadministration of amiodarone with sofosbuvir-containing regimens has been associated with serious symptomatic bradycardia, including fatalities and pacemaker placement. Risk is higher with beta blockers, underlying cardiac disease or advanced liver disease.
How serious is the interaction between Amiodarone and Ledipasvir-sofosbuvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible; if no alternative exists, monitor the heart rate in a hospital setting for at least the first 48 hours and then daily self-monitoring or outpatient checks for the first weeks.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
