Drug interactions
Amiodarone + Lidocaine
Severity: Moderate
Amiodarone and Lidocaine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone can raise systemic lidocaine concentrations, and reports describe lidocaine toxicity such as seizures or bradycardia. Amiodarone and lidocaine also share additive effects on cardiac conduction, so the combination may be more hazardous than the legacy rating implies.
What this interaction means in plain words
Amiodarone and Lidocaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Lidocaine belongs to Cardiovascular.
Why it happens
Amiodarone inhibits CYP3A4 (and CYP1A2) mediated lidocaine metabolism, with additive effects on cardiac conduction.
What to do
When giving intravenous lidocaine to patients on amiodarone, use the lowest effective dose and monitor ECG and for signs of neurotoxicity; check lidocaine levels in prolonged infusions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Lidocaine?
MediHelp rates the interaction as moderate. Amiodarone and Lidocaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone can raise systemic lidocaine concentrations, and reports describe lidocaine toxicity such as seizures or bradycardia. Amiodarone and lidocaine also share additive effects on cardiac conduction, so the combination may be more hazardous than the legacy rating implies.
How serious is the interaction between Amiodarone and Lidocaine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: When giving intravenous lidocaine to patients on amiodarone, use the lowest effective dose and monitor ECG and for signs of neurotoxicity; check lidocaine levels in prolonged infusions.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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