Drug interactions
Amiodarone + Lorlatinib
Severity: Moderate
Amiodarone and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib induces CYP3A4 and may lower amiodarone concentrations, reducing its antiarrhythmic effect. Lorlatinib also causes PR interval prolongation and AV block, which can add to amiodarone's conduction effects.
What this interaction means in plain words
Amiodarone and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Lorlatinib belongs to Oncology.
Why it happens
CYP3A4 induction by lorlatinib increases amiodarone clearance, with additive conduction effects.
What to do
Monitor ECG including PR interval and the antiarrhythmic response. Adjust amiodarone dose if arrhythmia control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Amiodarone with Lorlatinib?
MediHelp rates the interaction as moderate. Amiodarone and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib induces CYP3A4 and may lower amiodarone concentrations, reducing its antiarrhythmic effect. Lorlatinib also causes PR interval prolongation and AV block, which can add to amiodarone's conduction effects.
How serious is the interaction between Amiodarone and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG including PR interval and the antiarrhythmic response. Adjust amiodarone dose if arrhythmia control is lost.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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