Drug interactions
Amiodarone + Mavacamten
Severity: Major
Amiodarone and Mavacamten: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may raise mavacamten concentrations, which can excessively reduce left ventricular ejection fraction and precipitate heart failure.
What this interaction means in plain words
Amiodarone and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Mavacamten belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 (and CYP2C19) metabolism of mavacamten, increasing exposure.
What to do
Follow mavacamten labeling for dose adjustment and echocardiographic monitoring of LVEF when starting a moderate CYP3A4 inhibitor. Interrupt mavacamten if LVEF falls or heart failure symptoms develop.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Amiodarone with Mavacamten?
MediHelp rates the interaction as major. Amiodarone and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone may raise mavacamten concentrations, which can excessively reduce left ventricular ejection fraction and precipitate heart failure.
How serious is the interaction between Amiodarone and Mavacamten?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow mavacamten labeling for dose adjustment and echocardiographic monitoring of LVEF when starting a moderate CYP3A4 inhibitor. Interrupt mavacamten if LVEF falls or heart failure symptoms develop.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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