Drug interactions
Amiodarone + Meloxicam
Severity: Minor
Amiodarone and Meloxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits CYP2C9, one of the enzymes that metabolize meloxicam, which may modestly raise meloxicam exposure. This could increase the risk of gastrointestinal or renal adverse effects.
What this interaction means in plain words
Amiodarone and Meloxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Meloxicam belongs to Musculoskeletal.
Why it happens
Inhibition of CYP2C9-mediated meloxicam metabolism by amiodarone.
What to do
No routine adjustment is needed; use the lowest effective meloxicam dose and monitor for GI and renal adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Meloxicam?
MediHelp rates the interaction as minor. Amiodarone and Meloxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone inhibits CYP2C9, one of the enzymes that metabolize meloxicam, which may modestly raise meloxicam exposure. This could increase the risk of gastrointestinal or renal adverse effects.
How serious is the interaction between Amiodarone and Meloxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; use the lowest effective meloxicam dose and monitor for GI and renal adverse effects.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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