Drug interactions
Amiodarone + Metformin-pioglitazone
Severity: Minor
Amiodarone and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may modestly raise metformin concentrations, but the clinical significance is uncertain and the evidence is limited.
What this interaction means in plain words
Amiodarone and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Possible inhibition of renal tubular cation transporters (OCT2/MATE) that eliminate metformin; this is largely theoretical.
What to do
No routine change is needed; monitor glucose and renal function and watch for gastrointestinal intolerance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Amiodarone and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone may modestly raise metformin concentrations, but the clinical significance is uncertain and the evidence is limited.
How serious is the interaction between Amiodarone and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor glucose and renal function and watch for gastrointestinal intolerance.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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