Drug interactions
Amiodarone + Metformin-repaglinide
Severity: Moderate
Amiodarone and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may raise metformin exposure through competition for renal tubular secretion, increasing the risk of adverse effects such as lactic acidosis. Amiodarone may also inhibit CYP2C8 and CYP3A4 and increase repaglinide levels.
What this interaction means in plain words
Amiodarone and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Metformin-repaglinide belongs to Endocrine.
Why it happens
Inhibition of renal cationic transport (OCT2/MATE) reduces metformin clearance, and CYP2C8/3A4 inhibition reduces repaglinide metabolism.
What to do
Monitor renal function, glucose and signs of lactic acidosis or hypoglycemia. Adjust doses if glucose control changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Amiodarone and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may raise metformin exposure through competition for renal tubular secretion, increasing the risk of adverse effects such as lactic acidosis. Amiodarone may also inhibit CYP2C8 and CYP3A4 and increase repaglinide levels.
How serious is the interaction between Amiodarone and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, glucose and signs of lactic acidosis or hypoglycemia. Adjust doses if glucose control changes.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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