Drug interactions
Amiodarone + Morphine
Severity: Minor
Amiodarone and Morphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may modestly alter opioid exposure, but morphine is mainly cleared by glucuronidation, so the CYP2D6 route is minor. A clinically important effect is not well documented, although additive bradycardia or hypotension is possible.
What this interaction means in plain words
Amiodarone and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Morphine belongs to Musculoskeletal.
Why it happens
Amiodarone inhibits CYP2D6 and P-glycoprotein, which has limited relevance to morphine, as it is mainly glucuronidated.
What to do
No routine adjustment is needed; titrate morphine to response and monitor heart rate and blood pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Morphine?
MediHelp rates the interaction as minor. Amiodarone and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone may modestly alter opioid exposure, but morphine is mainly cleared by glucuronidation, so the CYP2D6 route is minor. A clinically important effect is not well documented, although additive bradycardia or hypotension is possible.
How serious is the interaction between Amiodarone and Morphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; titrate morphine to response and monitor heart rate and blood pressure.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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