Drug interactions
Amobarbital + Nateglinide
Severity: Moderate
Amobarbital and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes that metabolize nateglinide, which may reduce its glucose-lowering effect. Glycemic control could worsen when amobarbital is added, and hypoglycemia may occur if the barbiturate is stopped.
What this interaction means in plain words
Amobarbital and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Nateglinide belongs to Endocrine.
Why it happens
Induction of CYP2C9 and CYP3A4 by amobarbital increases nateglinide metabolism.
What to do
Monitor blood glucose when starting or stopping amobarbital. Adjust nateglinide dose according to glycemic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Amobarbital with Nateglinide?
MediHelp rates the interaction as moderate. Amobarbital and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes that metabolize nateglinide, which may reduce its glucose-lowering effect. Glycemic control could worsen when amobarbital is added, and hypoglycemia may occur if the barbiturate is stopped.
How serious is the interaction between Amobarbital and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping amobarbital. Adjust nateglinide dose according to glycemic response.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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