Drug interactions
Amiodarone + Nifedipine
Severity: Moderate
Amiodarone and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower heart rate and blood pressure, and amiodarone inhibits CYP3A4 and P-glycoprotein and can raise nifedipine exposure. This may cause hypotension, bradycardia or conduction disturbances.
What this interaction means in plain words
Amiodarone and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Nifedipine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects plus amiodarone inhibition of CYP3A4 metabolism of nifedipine.
What to do
Monitor blood pressure, heart rate and ECG. Reduce the nifedipine dose if hypotension or edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amiodarone and Nifedipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nifedipine
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Nifedipine?
MediHelp rates the interaction as moderate. Amiodarone and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower heart rate and blood pressure, and amiodarone inhibits CYP3A4 and P-glycoprotein and can raise nifedipine exposure. This may cause hypotension, bradycardia or conduction disturbances.
How serious is the interaction between Amiodarone and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG. Reduce the nifedipine dose if hypotension or edema develops.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
