Drug interactions
Amiodarone + Norgestrel
Severity: Minor
Amiodarone and Norgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone inhibits CYP3A4 and may modestly increase norgestrel exposure. The expected effect is a small increase in progestogenic adverse effects, with no loss of contraceptive efficacy.
What this interaction means in plain words
Amiodarone and Norgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Norgestrel belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated norgestrel metabolism by amiodarone.
What to do
No dose adjustment is usually needed. Monitor for progestogenic adverse effects such as breast tenderness or mood change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Norgestrel
- Amobarbital + Norgestrel Major
- Apalutamide + Norgestrel Major
- Bosentan + Norgestrel Major
- Carbamazepine + Norgestrel Major
- Efavirenz + Norgestrel Major
- Enzalutamide + Norgestrel Major
Frequently asked questions
Can I take Amiodarone with Norgestrel?
MediHelp rates the interaction as minor. Amiodarone and Norgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amiodarone inhibits CYP3A4 and may modestly increase norgestrel exposure. The expected effect is a small increase in progestogenic adverse effects, with no loss of contraceptive efficacy.
How serious is the interaction between Amiodarone and Norgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor for progestogenic adverse effects such as breast tenderness or mood change.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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