Drug interactions
Amiodarone + Sotorasib
Severity: Moderate
Amiodarone and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a P-gp inducer or modulator that might reduce amiodarone levels, though the clinical effect is not well characterized. Amiodarone is also a CYP3A4 substrate and sotorasib is a weak CYP3A4 inducer, so any reduction is likely modest.
What this interaction means in plain words
Amiodarone and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Sotorasib belongs to Oncology.
Why it happens
Sotorasib may alter P-gp efflux and weakly induce CYP3A4, potentially lowering amiodarone exposure.
What to do
Monitor heart rhythm control and consider checking ECG and clinical response when starting sotorasib. Adjust amiodarone dose if loss of effect is observed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Amiodarone with Sotorasib?
MediHelp rates the interaction as moderate. Amiodarone and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a P-gp inducer or modulator that might reduce amiodarone levels, though the clinical effect is not well characterized. Amiodarone is also a CYP3A4 substrate and sotorasib is a weak CYP3A4 inducer, so any reduction is likely modest.
How serious is the interaction between Amiodarone and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rhythm control and consider checking ECG and clinical response when starting sotorasib. Adjust amiodarone dose if loss of effect is observed.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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