Drug interactions
Amiodarone + Suvorexant
Severity: Moderate
Amiodarone and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone can raise suvorexant concentrations through weak to moderate CYP3A4 inhibition. This may increase next-day somnolence and impaired alertness or driving ability.
What this interaction means in plain words
Amiodarone and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Suvorexant belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated metabolism of suvorexant reduces its clearance.
What to do
Start suvorexant at a reduced dose (5 mg at bedtime) and titrate cautiously. Counsel the patient about next-day drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Suvorexant
Frequently asked questions
Can I take Amiodarone with Suvorexant?
MediHelp rates the interaction as moderate. Amiodarone and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone can raise suvorexant concentrations through weak to moderate CYP3A4 inhibition. This may increase next-day somnolence and impaired alertness or driving ability.
How serious is the interaction between Amiodarone and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start suvorexant at a reduced dose (5 mg at bedtime) and titrate cautiously. Counsel the patient about next-day drowsiness.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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