Drug interactions
Amiodarone + Tadalafil
Severity: Moderate
Amiodarone and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may modestly inhibit CYP3A4 and could raise tadalafil exposure, increasing vasodilatory adverse effects such as hypotension, headache and flushing. Both drugs may also affect cardiovascular status in patients with heart disease.
What this interaction means in plain words
Amiodarone and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Weak to moderate inhibition of CYP3A4-mediated tadalafil metabolism by amiodarone.
What to do
Monitor blood pressure and tolerability and consider a lower tadalafil dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Tadalafil?
MediHelp rates the interaction as moderate. Amiodarone and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may modestly inhibit CYP3A4 and could raise tadalafil exposure, increasing vasodilatory adverse effects such as hypotension, headache and flushing. Both drugs may also affect cardiovascular status in patients with heart disease.
How serious is the interaction between Amiodarone and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and tolerability and consider a lower tadalafil dose if adverse effects appear.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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