Drug interactions
Amiodarone + Tolterodine
Severity: Moderate
Amiodarone and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may inhibit CYP2D6 and CYP3A4 and raise tolterodine concentrations. Both drugs can prolong the QT interval, increasing proarrhythmic risk.
What this interaction means in plain words
Amiodarone and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Tolterodine belongs to Genitourinary.
Why it happens
Amiodarone inhibits CYP2D6 and CYP3A4, and both drugs have additive QT-prolonging effects.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes. Consider an alternative bladder agent if QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Tolterodine?
MediHelp rates the interaction as moderate. Amiodarone and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may inhibit CYP2D6 and CYP3A4 and raise tolterodine concentrations. Both drugs can prolong the QT interval, increasing proarrhythmic risk.
How serious is the interaction between Amiodarone and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes. Consider an alternative bladder agent if QT risk factors are present.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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