Drug interactions
Amiodarone + Trabectedin
Severity: Moderate
Amiodarone and Trabectedin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trabectedin is metabolized mainly by CYP3A4, and amiodarone may raise its concentrations. Higher exposure may increase hepatotoxicity, myelosuppression and other toxicities.
What this interaction means in plain words
Amiodarone and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Trabectedin belongs to Oncology.
Why it happens
Amiodarone inhibits CYP3A4-mediated metabolism of trabectedin.
What to do
Monitor liver enzymes, blood counts and CPK closely. Consider a non-interacting antiarrhythmic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Trabectedin
Frequently asked questions
Can I take Amiodarone with Trabectedin?
MediHelp rates the interaction as moderate. Amiodarone and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trabectedin is metabolized mainly by CYP3A4, and amiodarone may raise its concentrations. Higher exposure may increase hepatotoxicity, myelosuppression and other toxicities.
How serious is the interaction between Amiodarone and Trabectedin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes, blood counts and CPK closely. Consider a non-interacting antiarrhythmic if feasible.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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