Drug interactions
Amiodarone + Triamterene
Severity: Minor
Amiodarone and Triamterene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamterene is a cationic drug secreted by renal tubular transporters, and amiodarone has been proposed to compete for this pathway. The clinical significance is uncertain, and any rise in triamterene exposure would mainly increase hyperkalemia risk.
What this interaction means in plain words
Amiodarone and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amiodarone belongs to Cardiovascular; Triamterene belongs to Cardiovascular.
Why it happens
Possible competition for renal tubular secretion of cationic drugs; the mechanism is not firmly established.
What to do
Monitor serum potassium and renal function when the combination is used, especially in renal impairment. No dose change is needed routinely.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Triamterene?
MediHelp rates the interaction as minor. Amiodarone and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triamterene is a cationic drug secreted by renal tubular transporters, and amiodarone has been proposed to compete for this pathway. The clinical significance is uncertain, and any rise in triamterene exposure would mainly increase hyperkalemia risk.
How serious is the interaction between Amiodarone and Triamterene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function when the combination is used, especially in renal impairment. No dose change is needed routinely.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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