Drug interactions
Amiodarone + Vincristine
Severity: Moderate
Amiodarone and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may increase vincristine exposure, possibly worsening neurotoxicity such as peripheral neuropathy and constipation. The interaction is predicted from the mechanism with little direct clinical data.
What this interaction means in plain words
Amiodarone and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Vincristine belongs to Oncology.
Why it happens
Amiodarone inhibits P-glycoprotein and CYP3A4, reducing vincristine efflux and metabolism.
What to do
Monitor for neuropathy and bowel function, and reduce or hold vincristine if neurotoxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Amiodarone with Vincristine?
MediHelp rates the interaction as moderate. Amiodarone and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may increase vincristine exposure, possibly worsening neurotoxicity such as peripheral neuropathy and constipation. The interaction is predicted from the mechanism with little direct clinical data.
How serious is the interaction between Amiodarone and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy and bowel function, and reduce or hold vincristine if neurotoxicity develops.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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