Drug interactions
Amitriptyline + Aripiprazole
Severity: Moderate
Amitriptyline and Aripiprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined use may cause additive sedation and orthostatic hypotension, and a modest additive effect on QT is possible. Amitriptyline levels may also rise because aripiprazole is metabolised by CYP2D6, and CYP2D6 inhibitors can raise aripiprazole levels.
What this interaction means in plain words
Amitriptyline and Aripiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Aripiprazole belongs to Central Nervous System.
Why it happens
Additive CNS depressant and hypotensive effects, with possible minor additive QT effects and shared CYP2D6 metabolism.
What to do
Monitor for sedation, orthostasis and adverse effects when starting or changing doses. Consider an ECG in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amitriptyline and Aripiprazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Amitriptyline with Aripiprazole?
MediHelp rates the interaction as moderate. Amitriptyline and Aripiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combined use may cause additive sedation and orthostatic hypotension, and a modest additive effect on QT is possible. Amitriptyline levels may also rise because aripiprazole is metabolised by CYP2D6, and CYP2D6 inhibitors can raise aripiprazole levels.
How serious is the interaction between Amitriptyline and Aripiprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostasis and adverse effects when starting or changing doses. Consider an ECG in patients with cardiac risk factors.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
