Drug interactions
Amitriptyline + Atorvastatin
Severity: Minor
Amitriptyline and Atorvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atorvastatin is a weak P-glycoprotein inhibitor and could marginally raise amitriptyline exposure. No clinically significant effect has been established.
What this interaction means in plain words
Amitriptyline and Atorvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Atorvastatin belongs to Cardiovascular.
Why it happens
Possible weak inhibition of P-glycoprotein efflux by atorvastatin; clinical relevance is unproven.
What to do
No routine action is needed; be alert for anticholinergic or sedative effects of amitriptyline if symptoms emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Cyclosporine Major
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Atorvastatin?
MediHelp rates the interaction as minor. Amitriptyline and Atorvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atorvastatin is a weak P-glycoprotein inhibitor and could marginally raise amitriptyline exposure. No clinically significant effect has been established.
How serious is the interaction between Amitriptyline and Atorvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; be alert for anticholinergic or sedative effects of amitriptyline if symptoms emerge.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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