Drug interactions
Amitriptyline + Bazedoxifene-conjugated estrogens
Severity: Minor
Amitriptyline and Bazedoxifene-conjugated estrogens: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens may raise tricyclic antidepressant concentrations, increasing anticholinergic, sedative and cardiovascular adverse effects. Reports are inconsistent, and antidepressant response may also change.
What this interaction means in plain words
Amitriptyline and Bazedoxifene-conjugated estrogens have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amitriptyline belongs to Central Nervous System; Bazedoxifene-conjugated estrogens belongs to Endocrine.
Why it happens
Possible estrogen-mediated inhibition of tricyclic metabolism; mechanism not firmly established.
What to do
Monitor for tricyclic adverse effects and antidepressant response when estrogen is started or stopped, adjusting the tricyclic dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Frequently asked questions
Can I take Amitriptyline with Bazedoxifene-conjugated estrogens?
MediHelp rates the interaction as minor. Amitriptyline and Bazedoxifene-conjugated estrogens have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens may raise tricyclic antidepressant concentrations, increasing anticholinergic, sedative and cardiovascular adverse effects. Reports are inconsistent, and antidepressant response may also change.
How serious is the interaction between Amitriptyline and Bazedoxifene-conjugated estrogens?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and antidepressant response when estrogen is started or stopped, adjusting the tricyclic dose if needed.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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